Profhilo

Profhilo

Profhilo is an injectable skin treatment with one of the highest concentrations of hyaluronic acid available in aesthetics, used to hydrate, firm and remodel the skin rather than add volume. At Dr Elif Clinic, 54 Harley Street, London, a doctor injects Profhilo through five specific points on each side of the face, the skin looks brighter and smoother from around 2 weeks, and the effect can last up to six months.

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Profhilo at a glance

What it isA stabilised, high-concentration hyaluronic acid injectable
What it doesBoosts hydration and stimulates collagen and elastin for firmer, smoother, brighter skin
Adds volume?No – it spreads through the skin rather than filling a specific area
TechniqueVery fine needles at five specific points on each side of the face
ResultsVisible from around 2 weeks, improving over time
How long it lastsUp to six months, depending on the individual
Side effectsMild redness, bruising or tenderness at the injection points that fades quickly
Who performs itA doctor at Dr Elif Clinic, 54 Harley Street

What is Profhilo?

Profhilo is an injectable rejuvenation treatment made of hyaluronic acid. Its gel-like consistency distributes smoothly and evenly through the skin without forming lumps, which means it can be used in areas that are difficult to treat with traditional fillers. Instead of shaping or adding volume, it flows over a wider area to boost hydration and smooth and remodel the skin.

How does Profhilo work?

Once injected, Profhilo stays in the skin for around 28 days. During that time the slow release of hyaluronic acid stimulates several types of collagen and elastin. This is why Profhilo is more than a simple skin booster: as well as improving hydration and skin quality, it has a tightening and lifting effect on the tissue.

Who is Profhilo for?

As we age, the hyaluronic acid in the skin naturally decreases, and the skin gradually loses firmness and elasticity. Many people start to notice this in their 30s. Profhilo suits anyone who wants to improve skin quality – such as laxity, dullness and dehydration – without changing the shape of their face.

What happens during treatment?

  1. Consultation: your doctor assesses your skin and confirms whether Profhilo or another skin treatment is the best choice for you.
  2. Injection: Profhilo is injected with very fine needles at five specific points on each side of the face. Using a small number of points keeps the treatment simple and reduces the chance of pain or bruising.
  3. Spreading: because of its high concentration and cohesive nature, Profhilo starts spreading immediately and integrates evenly into your skin.
  4. Results: the skin looks brighter and smoother from around 2 weeks, and the effect continues to improve over time.

Profhilo, polynucleotides or filler?

ProfhiloHyaluronic acid – hydration, firmness and overall skin quality
PolynucleotidesPurified DNA fragments – regeneration and repair; popular for dark, crêpey under-eyes (polynucleotides)
Collagen biostimulatorsLonger-term collagen building, e.g. Sculptra and Juläine™
Dermal fillerVolume and shape for specific areas such as cheeks or lips

Your doctor will recommend the right option – or combination – for your skin at consultation.

Side effects and aftercare

Redness, bruising and tenderness at the injection points may occur. These are mild and fade quickly. Your aftercare is followed by your doctor, and you can contact the clinic directly by WhatsApp or phone.

Why choose Dr Elif Clinic for Profhilo?

Dr Elif Clinic is a doctor-led clinic at 54 Harley Street: every treatment is performed by a doctor. The clinic has been on Harley Street for 8 years, has seen more than 50,000 patients and holds a 4.9★ Google rating. Your doctor will only recommend Profhilo if it is the right treatment for your skin – and will tell you if another option would serve you better. Read patient reviews →

Profhilo FAQs

How long does Profhilo take to work?

You will usually see a difference around 2 weeks after treatment, with the skin looking brighter and smoother; the effect continues to improve over time.

How long does Profhilo last?

Up to six months, depending on the individual patient.

Is Profhilo a filler?

No. Profhilo spreads evenly through the skin to hydrate and remodel it; it does not add volume or change the shape of the face like a dermal filler.

Where is Profhilo injected?

At five specific points on each side of the face, using very fine needles.

Does Profhilo hurt?

The small number of injection points keeps the treatment quick and reduces the chance of pain or bruising.

What are the side effects of Profhilo?

Mild redness, bruising and tenderness at the injection points, which fade quickly.

What age is Profhilo for?

Many people start to notice the effects of hyaluronic acid loss in their 30s, but Profhilo can suit anyone who wants to improve skin quality.

Medically reviewed by Dr Elif Benar, Dermatologist, Dr Elif Clinic, 54 Harley Street, London. Last updated: October 2026.

Book a Profhilo consultation on Harley Street or call / WhatsApp +44 7979 725302.

Dr Elif Benar, medical doctor and dermatologist – Dr Elif Clinic, Harley Street London

Dr. Elif Benar

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